HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Toner, I. Articles by Smith, P. L. Search for Related Content PubMed PubMed Citation Articles by Toner, I. Articles by Smith, P. L.

European Journal of Cardio-Thoracic Surgery, Vol 11, 312-319, Copyright © 1997 by European Association for Cardio-thoracic Surgery

ARTICLES

EEG changes during cardiopulmonary bypass surgery and postoperative neuropsychological deficit: the effect of bubble and membrane oxygenators

I Toner, KM Taylor, g Lockwood, S Newman and PL Smith
Department of Cardiothoracic Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

OBJECTIVE: Quantitative electroencephalography was used during cardiopulmonary bypass surgery to determine the point in time of most neuronal functional change which may result in postoperative neuropsychological deficit. It was also used to determine any relationship between quantitative electroencephalography changes and type of oxygenator used in surgery. METHODS: We studied 61 coronary artery bypass graft patients. Anaesthesia included thiopental, fentanyl and N2O. Surgery was performed with hypothermic bypass (28 degrees C), arterial pressure of 50-70 mmHg, and alpha-stat, using bubble (Harvey 1700), or membrane (Cobe CML) oxygenators, both with arterial line filters (Pall 40 microns). RESULTS: The main finding was a significant increase in delta power at the end of perfusion (P < 0.01), which showed a positive association with delta power before the start of perfusion. Marked quantitative electroencephalography change at the end of perfusion was not related to systemic hypotension, temperature, type of oxygenator, bypass time, or patient age. Intraoperative quantitative electroencephalography changes found in most patients were transient and could not be related to postoperative cerebral function. However, 16 of the 18 patients who had neuropsychological deficit 2 months after surgery, also had a significant quantitative electroencephalography change at the end of perfusion. CONCLUSIONS: While no difference in anaesthetic technique was found between patients, the variation in quantitative electroencephalography power before perfusion may indicate a difference in individual response to anaesthetic. Usefulness of quantitative electroencephalography to predict postoperative cerebral functional deficit remains doubtful.

This article has been cited by other articles:

				D. van Dijk, A. M. A. Keizer, J. C. Diephuis, C. Durand, L. J. Vos, and R. Hijman Neurocognitive dysfunction after coronary artery bypass surgery: A systematic review J. Thorac. Cardiovasc. Surg., October 1, 2000; 120(4): 632 - 639. [Abstract] [Full Text] [PDF]

				I. Toner, K.M. Taylor, S. Newman, and P.L.C. Smith Cerebral functional changes following cardiac surgery: Neuropsychological and EEG assessment Eur. J. Cardiothorac. Surg., January 1, 1998; 13(1): 13 - 20. [Abstract] [Full Text] [PDF]