HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chow, G. Articles by Kirkham, F. J. Search for Related Content PubMed PubMed Citation Articles by Chow, G. Articles by Kirkham, F. J.

European Journal of Cardio-Thoracic Surgery, Vol 11, 633-639, Copyright © 1997 by European Association for Cardio-thoracic Surgery

ARTICLES

The relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass

G Chow, IG Roberts, P Fallon, M Onoe, A Lloyd-Thomas, MJ Elliott, AD Edwards and FJ Kirkham
Department of Neurosciences, Institute of Child Health/Great Ormond Street Hospital for Children, London, UK.

OBJECTIVES: Neurological impairment occurs in up to 25% of infants undergoing cardiopulmonary bypass with or without circulatory arrest. Potential causes include alterations in cerebral blood flow, hypoxia and embolisation. During cardiopulmonary bypass, arterial oxygen tension is maintained at levels which under normal conditions cause cerebral vasoconstriction; this is a potential mechanism for ischaemia. The aim of this study was to explore the relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass. METHODS: Near infrared spectroscopy was used to explore the relation between arterial oxygen tension and cerebral blood flow in 14 patients (median age 8 months; range 1 month to 10 years 11 months). The relations between arterial oxygen tension, arterial carbon dioxide tension, temperature, haematocrit, pump flow rate, mean arterial pressure and cerebral blood flow, were examined using multivariate analysis. RESULTS: There was no relation between cerebral blood flow and arterial oxygen tension, but a highly significant relation was observed between cerebral blood flow and pump flow rate, with cerebral blood flow decreasing 4.2-fold per L.m-2.min-1 decrease of pump flow rate. CONCLUSION: There was no relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass, but low pump flow rate may lead to reduced cerebral blood flow.

This article has been cited by other articles:

				M. J Elliott Recent advances in paediatric cardiopulmonary bypass Perfusion, July 1, 1999; 14(4): 237 - 246. [PDF]

				G. Chow, I. G. Roberts, A. D. Edwards, A. Lloyd-Thomas, A. Wade, M. J. Elliott, and F. J. Kirkham THE RELATION BETWEEN PUMP FLOW RATE AND PULSATILITY ON CEREBRAL HEMODYNAMICS DURING PEDIATRIC CARDIOPULMONARY BYPASS J. Thorac. Cardiovasc. Surg., October 1, 1997; 114(4): 568 - 577. [Abstract] [Full Text]