| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Eur J Cardiothorac Surg 2001;20:455-463
© 2001 Elsevier Science NL
a Department of Cardiothoracic Surgery, Royal Infirmary of Edinburgh and University of Edinburgh, Edinburgh, Scotland, UK
b Department of Clinical Neurosciences, Royal Infirmary of Edinburgh and University of Edinburgh, Edinburgh, Scotland, UK
c Department of Clinical and Surgical Sciences, Royal Infirmary of Edinburgh and University of Edinburgh, Edinburgh, Scotland, UK
d Department of Anaesthetics, Royal Infirmary of Edinburgh and University of Edinburgh, Edinburgh, Scotland, UK
Received 9 March 2001; received in revised form 18 April 2001; accepted 31 May 2001.
Corresponding author. Tel.: +44-131-536-4183; fax: +44-131-229-0659
e-mail: wsw{at}holyrood.ed.ac.uk
Objectives: Major thoracic surgery is associated with trauma-related immunological changes. These may impair anti-tumour immunity. We hypothesize that the reduced operative trauma associated with a video-assisted thoracic surgery (VATS) approach may decrease acute phase responses and, consequently, lead to better preservation of immune function. This prospective randomized study compared the effects of conventional open thoracic surgery and VATS on acute phase responses in patients undergoing pulmonary lobectomy. Methods: Acute phase indicators were analyzed in patients undergoing lobectomy for suspected bronchogenic carcinoma. Surgery was prospectively randomized to pulmonary lobectomy by VATS or limited postero-lateral thoracotomy. Blood was taken pre-operatively and at 4, 24, 48, 72, 120 and 168 h post-operatively for analysis of C-reactive protein (CRP; 41 patients: open, n=22; VATS, n=19) interleukin (IL)-6, tumour necrosis factor (TNF) receptors (TNF-sR55, TNF-sR75) and P-selectin (24 patients: open, n=12; VATS, n=12). Samples taken at 48 and 168 h were also analyzed for phagocyte reactive oxygen species (ROS) production (25 patients: open, n=16; VATS, n=19). Results: Surgery increased acute phase responses. VATS was associated with lower CRP and IL-6 levels. In the open surgery group, significant increases in ROS in neutrophils (up to 36% greater than before surgery, n=12, P<0.02–0.05) were detected at 2 days after surgery, but in the VATS group, the increase after surgery (of up to 17%, n=18) did not reach significance. Similarly, monocyte ROS increases of up to 25% in the mean ROS in the open surgery group and of up to 17% in the VATS group were detected on days 2 and 7 after surgery. Conclusions: VATS pulmonary lobectomy is associated with reduced peri-operative changes in acute phase responses. This finding may have implications for peri-operative tumour immuno-surveillance in lung cancer patients.
Key Words: Acute phase • Cytokine • Minimally invasive surgery
This article has been cited by other articles:
|
|
 |
|
  A. Tajima, M. Kohno, M. Watanabe, Y. Izumi, S. Tasaka, I. Maruyama, T. Miyasho, and K. Kobayashi Occult injury in the residual lung after pneumonectomy in mice Interactive CardioVascular and Thoracic Surgery, December 1, 2008; 7(6): 1114 - 1120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. O. Jones, G. Casali, and W. S. Walker Does failed video-assisted lobectomy for lung cancer prejudice immediate and long-term outcomes? Ann. Thorac. Surg., July 1, 2008; 86(1): 235 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Nicastri, J. P. Wisnivesky, V. R. Litle, J. Yun, C. Chin, F. R. Dembitzer, and S. J. Swanson Thoracoscopic lobectomy: Report on safety, discharge independence, pain, and chemotherapy tolerance J. Thorac. Cardiovasc. Surg., March 1, 2008; 135(3): 642 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Flores and N. Alam Video-Assisted Thoracic Surgery Lobectomy (VATS), Open Thoracotomy, and the Robot for Lung Cancer Ann. Thorac. Surg., February 1, 2008; 85(2): S710 - S715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Demmy and C. Nwogu Is Video-Assisted Thoracic Surgery Lobectomy Better? Quality of Life Considerations Ann. Thorac. Surg., February 1, 2008; 85(2): S719 - S728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Szczesny, R. Slotwinski, B. Szczygiel, A. Stankiewicz, M. Zaleska, M. Kopacz, and A. Olesinska-Grodz Systematic mediastinal lymphadenectomy does not increase postoperative immune response after major lung resections Eur. J. Cardiothorac. Surg., December 1, 2007; 32(6): 868 - 872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Swanson, J. E. Herndon II, T. A. D'Amico, T. L. Demmy, R. J. McKenna Jr, M. R. Green, and D. J. Sugarbaker Video-Assisted Thoracic Surgery Lobectomy: Report of CALGB 39802 A Prospective, Multi-Institution Feasibility Study J. Clin. Oncol., November 1, 2007; 25(31): 4993 - 4997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Solli and L. Spaggiari Indications and Developments of Video-Assisted Thoracic Surgery in the Treatment of Lung Cancer Oncologist, October 1, 2007; 12(10): 1205 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Schilling, A. Kozian, M. Kretzschmar, C. Huth, T. Welte, F. Buhling, G. Hedenstierna, and T. Hachenberg Effects of propofol and desflurane anaesthesia on the alveolar inflammatory response to one-lung ventilation Br. J. Anaesth., September 1, 2007; 99(3): 368 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Szczesny, R. Slotwinski, A. Stankiewicz, B. Szczygiel, M. Zaleska, and M. Kopacz Interleukin 6 and interleukin 1 receptor antagonist as early markers of complications after lung cancer surgery Eur. J. Cardiothorac. Surg., April 1, 2007; 31(4): 719 - 724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. West, S. Rashid, and J. Dunning Does video-assisted thoracoscopic lobectomy produce equal cancer clearance compared to open lobectomy for non-small cell carcinoma of the lung? Interactive CardioVascular and Thoracic Surgery, February 1, 2007; 6(1): 110 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Friscia, J. Zhu, J. W. Kolff, Z. Chen, L. R. Kaiser, C. S. Deutschman, and J. B. Shrager Cytokine Response is Lower After Lung Volume Reduction Through Bilateral Thoracoscopy Versus Sternotomy Ann. Thorac. Surg., January 1, 2007; 83(1): 252 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Amar, A. Goenka, H. Zhang, B. Park, and H. T. Thaler Leukocytosis and increased risk of atrial fibrillation after general thoracic surgery. Ann. Thorac. Surg., September 1, 2006; 82(3): 1057 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Froudarakis, M. Klimathianaki, and M. Pougounias Systemic inflammatory reaction after thoracoscopic talc poudrage. Chest, February 1, 2006; 129(2): 356 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jinbo, K. Ueda, Y. Kaneda, M. Sudo, T.-S. Li, and K. Hamano Video-assisted transcatheter lung perfusion regional chemotherapy Eur. J. Cardiothorac. Surg., June 1, 2005; 27(6): 1079 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. Grichnik and T. A. D'Amico Acute Lung Injury and Acute Respiratory Distress Syndrome After Pulmonary Resection Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2004; 8(4): 317 - 334. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Sedrakyan, J. van der Meulen, J. Lewsey, and T. Treasure Video assisted thoracic surgery for treatment of pneumothorax and lung resections: systematic review of randomised clinical trials BMJ, October 30, 2004; 329(7473): 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Endo, Y. Sato, T. Hasegawa, K. Tetsuka, S. Otani, N. Saito, Y. Tezuka, and Y. Sohara Preoperative chemotherapy increases cytokine production after lung cancer surgery Eur. J. Cardiothorac. Surg., October 1, 2004; 26(4): 787 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gharagozloo, B. Tempesta, M. Margolis, and E. P. Alexander Video-assisted thoracic surgery lobectomy for Stage I lung cancer Ann. Thorac. Surg., October 1, 2003; 76(4): 1009 - 1015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Walker, M. Codispoti, S. Y. Soon, S. Stamenkovic, F. Carnochan, and G. Pugh Long-term outcomes following VATS lobectomy for non-small cell bronchogenic carcinoma Eur. J. Cardiothorac. Surg., March 1, 2003; 23(3): 397 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Thomas, C. Doddoli, S. Yena, X. Thirion, F. Sebag, P. Fuentes, and R. Giudicelli VATS is an adequate oncological operation for stage I non-small cell lung cancer Eur. J. Cardiothorac. Surg., June 1, 2002; 21(6): 1094 - 1099. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
