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Eur J Cardiothorac Surg 2001;20:901-907
© 2001 Elsevier Science NL

On-pump versus off-pump coronary artery bypass: independent risk factors and off-pump graft patency

Ole Lunda, John Christensena, Susanne Holmea, Kim Fruergaardb, Arne Olesena, Eli Kassisc, Ulrik Abildgaardc

a Department of Cardio-thoracic Surgery, Copenhagen University Hospital in Gentofte, Copenhagen, Denmark
b Department of Anesthesiology, Copenhagen University Hospital in Gentofte, Copenhagen, Denmark
c Department of Cardiology, Copenhagen University Hospital in Gentofte, Copenhagen, Denmark

Received 2 April 2001; received in revised form 29 July 2001; accepted 17 August 2001.

Corresponding author. Cardiothoracic Surgery Unit, Glasgow Royal Infirmary, 16 Alexandra Parade, Glasgow G31 2ER, UK. Tel.: +44-141-211-4733; fax: +44-141-211-4845
e-mail: olelund{at}btopenworld.com

Objective: Current knowledge on off-pump coronary artery bypass (OPCAB) generally stems from single surgeons’ experience or from series where OPCABs constituted a minor fraction of coronary operations. The present center decided to venture as far into OPCAB as possible during 1999. The present series thus represents the average surgeon's experience. Methods: During 1999, 533 patients underwent coronary artery bypass grafting using cardiopulmonary bypass (CPB) in 368 and OPCAB in 165 including the circumflex artery (CX) area in 91. Coronary arteriography was performed before discharge in the first 103 OPCAB patients. Results: The CPB and OPCAB groups differed as regards left ventricular ejection fraction (53±13 versus 57±11, P<0.0001) and frequency of triple-vessel or left main stem disease (84 versus 32%, P<0.0001) but were comparable as regards diabetes (12%), prior myocardial infarct (57%), unstable angina (21%), and previous heart surgery (3%). Using multivariate analyses, 30-day mortality (1.3%), P-creatine kinase myocardial band (CKMB) >80 µg/l (11.1%), re-sternotomy for bleeding (4.5%) or dehiscense (1.7%), transitory cerebral ischemia and stroke (1.7%), supraventricular tachycardia (27.4%), and hospital stay (mean 8 days) were unrelated to off- versus on-pump surgery as well as to OPCAB in triple-vessel disease. CX branches <=1 mm, >=5 distal anastomoses, prior heart surgery, right coronary artery (RCA) branches <=1.5 mm, 8–21 days old myocardial infarct, female gender, and preoperative acute arrhythmia (among others) were identified as independent risk factors for mortality or increased CKMB in all 533 patients. The latter five risk factors were reproduced in the OPCAB group isolated. The patency in the 103 OPCABs was 95.3, 91.8, and 85.3% in the left anterior descending artery (LAD), CX, and RCA, respectively. Patency was inversely related to diameter of the grafted vessel in the LAD and CX areas, unlike the RCA area. Conclusions: The results after beating heart surgery were good also in patients with triple-vessel disease, but specific gains relative to on-pump surgery could not be shown. The independent risk factors in the OPCAB group may indicate relative contraindications for OPCAB grafting.

Key Words: Coronary bypass grafting • Off pump • Beating heart • Cardiopulmonary bypass • Graft patency




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