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Eur J Cardiothorac Surg 2002;22:70-77
© 2002 Elsevier Science NL
a Department of Cardio-Thoracic Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
b Department of Cardio-Thoracic Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands
c Department of Cardio-Thoracic Surgery, University Medical Center Leiden/Academic Medical Center, Amsterdam, The Netherlands
d Department of Cardio-Thoracic Surgery, University Medical Center Nijmegen, Nijmegen, The Netherlands
e Department of Cardio-Thoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
f Department of Cardio-Thoracic Surgery, University Medical Center Groningen, Groningen, The Netherlands
Received 18 December 2001; received in revised form 22 February 2002; accepted 22 March 2002.
* Corresponding author. Tel.: +31-10-463-5413; fax: +31-10-463-3993
e-mail: takkenberg{at}thch.azr.nl
Objective: Limited information is available on outcome after autograft aortic valve replacement, in particular with respect to the durability of the autograft and of the allograft used to reconstruct the right ventricular outflow tract. A retrospective follow-up study of all patients who underwent a Ross procedure in the Netherlands since 1988 was done to obtain an overview of the Dutch experience with this procedure. Methods: From 1988 to January 2000, 348 Ross procedures were performed in nine centers in the Netherlands. Pre-operative, peri-operative and follow-up data from 343 patients in seven centers (99% of all Dutch autograft patients) were collected and analyzed. Results: Mean patient age was 26 years (SD 14, range 0–58) and male/female ratio was 2.1. Bicuspid valve or other congenital heart valve disease was the most common indication for operation. The root replacement technique was used in 95% of patients and concomitant procedures were done in 12%. Hospital mortality was 2.6% (N=9). Mean follow-up was 4 years (median 3.8, SD 2.8, range 0–12.5). Overall cumulative survival was 96% at 1 year (95% confidence interval (CI) 94–98%) and 94% at 5 and 7 post-operative years, respectively (95% CI 91–97%). At last follow-up, 87% of the surviving patients was in New York Heart Association (NYHA) class I. Independent predictors of overall mortality were pre-operative NYHA class IV/V and longer perfusion time. Autograft reoperation had to be performed in 14 patients and reintervention on the pulmonary allograft in 10 patients. Freedom from any valve-related reintervention was 88% at 7 years (95% CI 81–94%). Conclusions: The Dutch experience with the Ross procedure is favorable, with low operative mortality and good mid-term results. Although both the autograft in aortic position and the allograft in the right ventricular outflow tract have a limited durability, this has not yet resulted in considerable reoperation rates and associated morbidity and mortality.
Key Words: Ross procedure • Autograft • Allograft • Multicenter study • Clinical outcome
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