HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Akif Turna Muzaffer Metin Adnan Sayar Atilla Gürses Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Turna, A. Articles by Gürses, A. Search for Related Content PubMed PubMed Citation Articles by Turna, A. Articles by Gürses, A. Related Collections Lung - cancer

Eur J Cardiothorac Surg 2004;26:483-487
© 2004 Elsevier Science NL

Lactate dehydrodgenase levels predict pulmonary morbidity after lung resection for non-small cell lung cancer

Akif Turna^a*, Okan Solak^a, Erdoan Çetinkaya^b, Ali Klçgün^a, Muzaffer Metin^a, Adnan Sayar^a, Atilla Gürses^a

^a Department of Thoracic Surgery, Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul, Turkey
^b Department of Chest Diseases, Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul, Turkey

Received 29 January 2004; received in revised form 17 May 2004; accepted 26 May 2004.

^* Corresponding author. Cami Sok. Muminderesi Yolu. No. 32/22, Emintas, Sahrayicedid, Kafikoy, Istanbul 81080, Turkey. Tel.: +90-216-411-36-75; fax: +90-212-411-66-51
e-mail: aturna{at}turk.net

Objective: The prevention of pulmonary complication after pulmonary resection for non-small cell lung cancer may minimize postoperative mortality rates and hospitalization period. The purpose of this study was to identify preoperative factors associated with the development of pulmonary complications after lung resections to help predict which patients are at increased risk for morbidity. Methods: From January 2000 to June 2003, 108 consecutive pulmonary resections were performed for non-small cell lung cancer in our institution. The following information was recorded: demographic, clinical, functional, and surgical variables. We evaluated all complications, which arose after pulmonary resection during hospitalization. The risk of complication was evaluated using univariate and multiple logistic regression analysis to estimate odds ratio. Results: Sixty-six lobectomies, 31 pneumonectomies, 11 bilobectomies and four wedge resections were done. Forty-nine complications were realized in all patients. A logistic regression analysis on relevant variables showed that only the increased serum lactate dehydrogenase (LDH) levels (>320 U/l) was a significant predictor of a pulmonary complication (P=0.03). Age, side of resection, low FEV₁, stage of the disease, low partial arterial oxygen pressure, low partial arterial carbon dioxide pressure, cigarette smoking and concomitant disease were not significant predictors of morbidity. Conclusion: Patients who have higher serum LDH levels are at increased risk for developing postoperative morbidity. Postoperative physical therapy and medical care might be intensified in those patients at high risk.

Key Words: Lung cancer • Complication • Morbidity • Lactate dehydrogenase

This article has been cited by other articles:

				S. R. Bapoje, J. F. Whitaker, T. Schulz, E. S. Chu, and R. K. Albert Preoperative Evaluation of the Patient With Pulmonary Disease Chest, November 1, 2007; 132(5): 1637 - 1645. [Abstract] [Full Text] [PDF]

				A. Turna and E. Cetinkaya Reply to Olgac et al. Eur. J. Cardiothorac. Surg., April 1, 2005; 27(4): 733 - 734. [Full Text] [PDF]

				G. Olgac, A. Olcmen, and C. A. Kutlu Is lactate dehydrogenase level really a reliable predictor of pulmonary morbidity than other co-morbid parameters following lung resection for NSCLC? Eur. J. Cardiothorac. Surg., April 1, 2005; 27(4): 732 - 733. [Full Text] [PDF]